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Cytochrome P450 Detoxification Pathway:
Cytochrome P450 Homepage David Nelson, Assistant Professor, University of Tennessee: Health Sciences Center. Homepage for Cytochrome P450 nomenclature.
Cytochrome P450s in Humans by David Nelson Ph.D. "Cytochrome P450 proteins in humans are drug metabolizing enzymes and enzymes that are used to make cholesterol, steroids and other important lipids such as prostacyclins and thromboxane A2. These last two are metabolites of arachidonic acid. Mutations in cytochrome P450 genes or deficiencies of the enzymes are responsible for several human diseases. Induction of some P450s is a risk factor in several cancers since these enzymes can convert procarcinogens to carcinogens..."
Cytochrome P450 Reductase Todd D. Porter, PhD, Pharmaceutical Sciences, University of Kentucky. Includes information on: Biology of Cytochrome P450 Reductase, Discovery and Characterization, Expression and Regulation, Analysis of the CPR Gene, Enzymology of Cytochrome P450 Reductase, Flavins and Electron Transfer, NADPH Binding, Electron Transfer to Cytochrome P450, Structure of Cytochrome P450 Reductase.
Detoxification Enzyme Systems (The) by DeAnn J. Liska, Ph.D. "... The scientific literature suggests an association between impaired detoxification and certain diseases, including cancer, Parkinson's disease, fibromyalgia, and chronic fatigue/immune dysfunction syndrome. Data regarding these hepatic detoxification enzyme systems and the body's mechanisms of regulating them suggests the ability to efficiently detoxify and remove xenobiotics can affect these and other chronic disease processes. This article reviews the myriad detoxification enzyme systems; their regulatory mechanisms; and the dietary, lifestyle, and genetic factors influencing their activities; as well as laboratory tests available to assess their functioning..."
Directory of P450-containing Systems The goal of this www Directory is to facilitate access to electronic resources world-wide for all researchers working in the field of P450 proteins and P450-containing systems. Databases currently linked are: SWISS-PROT, EMBL, PDB, Entrez, PROSITE, PRINTS, ENZYME, and LIGAND.
Mitochondrial carriers by David Nelson, Ph.D.
Regulation of P450 gene expression; structural basis for cellular localization, membrane association, assembly, and substrate interaction of P450 Byron W. Kemper, Department of Cell and Structural Biology, University of Illinois.
Enzyme Database "BRENDA" Comprehensive Enzyme Information System.
Dave Flockart's Drug Interactions Indiana University Dept. of Medicine. Cytochrome P450 Drug-Interaction Table. Clinically Relevant D-I Table. This table is designed as a hypothesis testing, teaching and reference tool for physicians and researchers interested in drug interactions that are the result of competition for, or effects on the human cytochrome P450 system.
Induction of P450 by St. John's Wort St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Abstract. Proc Natl Acad Sci U S A 2000 Jun 20;97(13):7500-2. PMID: 10852961 [PubMed - indexed for MEDLINE].
Inhibition of P450 by St. John's Wort Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression. Abstract. Obach RS. J Pharmacol Exp Ther 2000 Jul;294(1):88-95. PMID: 10871299 [PubMed - indexed for MEDLINE].
P450 Metabolism Managing Drug Interactions. Includes various links to other regularly updated p450 drug-interaction sites.
Researchers find important use for grapefruit beyond breakfast Compound inhibits enzymes that metabolize drugs in humans.
Xenobiotic-Metablolizing Enzymes in Biomarker Research Biomarkers and Occupational Health: Progress and Perspectives. 1995. National Academy Press, p 238-256.
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